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KMID : 0359819960250030627
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Journal of Korean Neurosurgical Society
1996 Volume.25 No. 3 p.627 ~ p.634
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Preliminary Result of Epilepsy Surgery in Patients with Neuronal Migration Disorder
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황승균
정천기/오창완/이상건/지제근/김현집/한대희/이상복
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Abstract
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Neuronal migration disorders (NMD's) are a rare group of developmental structural lesions characterized by disorganization of cortical architecture with aberrant columnar and laminar neuronal arrangement often causing intractable seizures.
During September 1994 to February 1995. we operated on six patients with NMD to treat intractable seizures. Male to female ratio of these 6 patients was 2:4 and mean age at seizure onset was 14 years old (range 6-28 years). indicating early onset
of
epilepsy Mean age at seizure surgery was 29 years old (range 23-41 years). and mean follow-up duration after operation was 4 months (range 3-6 months). In their bast medical history. three patients had experienced febrile seizure at pediatric
age.
and
one of them had a history of anoxic damage during delivery Following preoperative localization. the lesion was removed completely in five patients. In the other one patient. part of the lesion was located in the speech and motor area. leading to
partial
removal On histologic examination. two of then showed cortical dysplasia and the other four revealed microdysgenesis. During follow up for six months five patients were free of seizure and in the other one patient. whose lesion was removed
incompletely.
the frequency of seizure decreased by 95%.
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KEYWORD
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